Low dopamine transporter binding in the nucleus accumbens in geriatric patients with severe depression

• DOI: 10.1111/pcn.13020
• Publication Date: 2020-05-04T04:04:32Z
• Authors: Hiroki Moriya; Mikael Tiger; Amane Tateno; Takeshi Sakayori; Takahiro Masuoka; WooChan Kim; Ryosuke Arakawa; Yoshiro Okubo
• Keywords: Putamen; Caudate nucleus

Aim Dysfunction of dopaminergic neurons in the central nervous system is considered to be related major depressive disorder (MDD). Especially, MDD geriatric patients characterized by anhedonia, which assumed associated with reduced dopamine neurotransmission reward system. Dopamine transporter (DAT) reflect function nerve However, previous DAT imaging studies using single photon emission computed tomography or positron (PET) have shown inconsistent results. The radioligand [ 18 F]FE‐PE2I for PET enables more precise evaluation availability. Hence, we aimed evaluate availability F]FE‐PE2I. Methods Eleven severe and 27 healthy controls underwent F]FE‐PE2I, has high affinity selectivity DAT. Binding potentials ( BP ND ) striatum (caudate putamen), nucleus accumbens (NAc), substantia nigra were calculated. values compared between controls. Results showed significantly lower NAc P = 0.009), there was a trend putamen 0.032) Conclusion We found low MDD, could dysregulation