Abnormal gut microbiota and bile acids in patients with first‐episode major depressive disorder and correlation analysis

• DOI: 10.1111/pcn.13368
• Publication Date: 2022-04-21T10:05:20Z
• Authors: Ning Sun; Jie Zhang; Jizhi Wang; Zhifen Liu; Xin Wang; Pengli Kang; Chunxia Yang; Penghong Liu; Kerang Zhang
• Keywords: Lithocholic acid

Gut microbiota and its metabolite bile acids may play a significant role in the occurrence development of major depressive disorder (MDD). Therefore, this study analyzes gut acids, as well their correlation patients.Thirty-one patients with MDD 29 healthy controls (HCs) were enrolled study. We collected both blood feces. Plasma acid content was determined by liquid chromatography-mass spectrometry detected 16SrRNA gene sequencing subsequently analyzed. also analyzed between different microbiota, Hamilton Depression (HAMD) score.The α-diversity analysis found that Simpson Pielou evenness index much higher HCs than MDD. The β-diversity two groups differences nonmetric multidimensional scaling analysis. Linear discriminant effect size identified 16 strains. Bile detection showed 23-nordeoxycholic significantly HCs, whereas taurolithocholic (TLCA), glycolithocholic (GLCA), lithocholic 3-sulfate lower. Spearman Turicibacteraceae, Turicibacterales, Turicibacter positively related TLCA, GLCA, glycodeoxycholic (GDCA), taurodeoxycholic acid, negatively correlated HAMD score. At same time, GDCA score.Gut metabolism are disturbances MDD, there exists metabolism. Moreover, interaction be to pathophysiological mechanism