A community divided: Post‐transplant live vaccine practices among Society of Pediatric Liver Transplantation (SPLIT) centers

• DOI: 10.1111/petr.13804
• Publication Date: 2020-09-02T17:29:11Z
• Authors: Sarah Kemme; Shikha S. Sundaram; Donna J. Curtis; Steven Lobritto; Saeed Mohammad; Amy G. Feldman
• Keywords: Immunosuppression

Abstract Background Historically, the IDSA and AST have recommended that live vaccines not be administered post‐transplant due to concern for induction of vaccine‐strain disease in immunocompromised hosts. However, recent prospective studies revised guidelines published April 2019 suggest current era immunosuppression minimization, may safely select transplant recipients with resulting immunoprotection. The goal this study was assess vaccine practices at individual pediatric liver centers following updated guidelines. Methods A six‐item email survey detailing center‐specific followed by up three response‐specific questions were distributed between July May 2020 a representative from each center participating SPLIT consortium. Results overall response rate 93% (41/44 centers). Only 29% (12/41) offer post‐transplant; these 12 uses different eligibility criteria vaccines. There no difference large (ten or more transplants per year) small (less than ten likelihood post‐transplant. main reasons offering safety concerns inability reach group consensus. Conclusions majority are reluctant despite Prospective multicenter needed confirm immunogenicity