Host Th1/Th2 immune response to Taenia solium cyst antigens in relation to cyst burden of neurocysticercosis

• DOI: 10.1111/pim.12351
• Publication Date: 2016-08-05T07:16:15Z
• Authors: J. Tharmalingam; A. T. Prabhakar; P. Gangadaran; P. Dorny; J. Vercruysse; P. Geldhof; V. Rajshekhar; M. Alexander; A. Oommen
• Keywords: Neurocysticercosis; Taenia solium

Neurocysticercosis (NCC), Taenia solium larval infection of the brain, is an important cause acquired seizures in endemic countries, which relate to number, location and degenerating cysts brain. Multicyst infections are common countries although single-cyst prevails India. Single-cyst country suggest a role for host immunity limiting infection. This study examined ex vivo CD4(+) T cells vitro Th1 Th2 cytokine responses T. cyst antigens peripheral blood mononuclear healthy subjects from nonendemic regions single- multicyst-infected patients association with burden NCC. elicited response solium-endemic solium-non-endemic those multicyst neurocysticercosis. neurocysticercosis also exhibited low levels effector memory cells. exposure infectious loads may aid number. cytokines enable multiple-cyst establish persist.