Distinct DC subsets regulate adaptive Th1 and 2 responses during Trichuris muris infection

• DOI: 10.1111/pim.12458
• Publication Date: 2017-08-12T14:26:35Z
• Authors: M. Demiri; K. Müller‐Luda; W. W. Agace; M. Svensson‐Frej
• Keywords: Trichuris; Clearance; Mesenteric lymph nodes; Intestinal mucosa

Low- and high-dose infections with the murine large intestinal nematode Trichuris muris are associated induction of adaptive Th1 Th2 responses, respectively, in mesenteric lymph nodes (MLN). Classical dendritic cells (cDC) accumulate mucosa MLN upon T. infection, yet their role driving responses to infection remains largely unknown. We performed low- mice deficient defined cDC subsets investigate immune responses. Mice lacking IRF4-dependent failed clear a displayed impaired Conversely, IRF8-dependent cleared low-dose an response while increased production cytokines. Finally, both IRF4- were able generate infection. Collectively, these results suggest that act antagonistically during demonstrate can be generated towards absence cDC.