Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia

• DOI: 10.1111/resp.14893
• Publication Date: 2025-02-06T07:21:37Z
• Authors: Yunqing Zhu; Yongbing Lan; Jun Lv; Dianjianyi Sun; Pei Pei; Ling Yang; Iona Y. Millwood; Robin G. Walters; Yiping Chen; Huaidong Du; Jian Wang; Xiaoming Yang; Rebecca Stevens; Junshi Chen; Zhengming Chen; Liming Li; Canqing Yu
• Keywords: Mendelian Randomization

ABSTRACT Background and Objective Previous observational studies reported a complex relationship between snoring coronary artery disease (CAD). We aimed to estimate the causal associations CAD among East Asian people, effects independent of BMI. Methods Based on 497,250 adults from China Kadoorie Biobank (CKB), we performed conventional prospective analysis outcomes, using multivariable Cox regression. also leveraged genome‐wide association (GWAS) summary statistics BMI CKB ( n = 100,626, 47,208 snorers) outcomes Japan (BBJ, 5891–25,892 cases, 142,336–168,186 controls). Single‐variable two‐sample bi‐directional Mendelian randomization (MR) analyses were performed. Results During median follow‐up 12.32 years, 48,997 participants developed CAD. Snoring habitual associated with incident myocardial infarction (MI), was stable angina pectoris (SAP). The HRs (95% CIs) 1.06 (1.04, 1.08), 1.08) 1.14 (1.03, 1.25). remained non‐adiposity participants. Genetically predicted MI, corresponding IVW‐ORs 1.09 (1.005, 1.19) 1.15 (1.05, Further adjusted BMI, retained MI CAD, showed impact SAP (1.09 [1.01, 1.17]). No reverse observed CADs traits. Conclusion Habitual elevated risks total SAP. These findings indicated that intervention might contribute decrease risk Asians.