The role of viscosity on skin penetration from cellulose ether‐based hydrogels

• DOI: 10.1111/srt.12709
• Publication Date: 2019-05-07T05:59:16Z
• Authors: Lisa Binder; Julia Mazál; Romana Petz; Victoria Klang; Claudia Valenta
• Keywords: Penetration (warfare); Microviscosity

Abstract Background The rheological properties of dermal drug delivery systems are importance when designing new formulations. Viscosity not only affects features such as spreadability and skin feel, but may also affect the penetration incorporated actives. Data on latter aspect controversial. Our objective was to elucidate relation between viscosity performance different model hydrogels assuming that enhanced microviscosity might delay release penetration. Materials Methods Hydrogels covering a broad range were prepared by adding either HPMC or HEC gelling agents in concentrations. To investigate ability gels deliver into skin, sulphadiazine sodium its vitro monitored using tape stripping/HPLC analysis non‐invasive confocal Raman spectroscopy. Results trends observed with two experimental setups comparable. Drug depths decreased slightly increasing viscosity, suggesting slower due increasingly dense gel networks. However, total penetrated amounts independent exact formulation viscosity. Conclusion largely unaffected hydrogel Moderately is advisable cellulose ether allow for convenient application.