Endemic outbreaks due to the re‐emergence of classical swine fever after accidental introduction of modified live LOM vaccine on Jeju Island, South Korea

• DOI: 10.1111/tbed.13121
• Publication Date: 2019-01-12T14:23:01Z
• Authors: Guehwan Jang; Joo‐Ah Kim; Won‐Myoung Kang; Hyoung‐Seok Yang; Changnam Park; Kyongju Jeong; Sung‐Up Moon; Choi‐Kyu Park; Young S. Lyoo; Changhee Lee
• Keywords: Accidental; Classical swine fever

After the unintentional vaccination of LOM vaccine strain in 2014, classical swine fever virus (CSFV) reemerged naïve pig herds on Jeju Island, South Korea, which had been a CSF-free region with non-vaccination policy for decade. Since re-emergence, endemic outbreaks CSFV have occurred island, causing enormous damage to provincial farms. The present study reports complete genome sequences and molecular characterization LOM-derived field strains responsible current Island. emergent isolates shared 98.9%–99.7% 98.7%–99.0% nucleotide sequence identity at E-gene whole-genome levels compared respectively. Genetic phylogenetic analyses indicated that were closest strains, but appeared undergone substantial evolution. total number amino acid differences between ranged from 111 28 148 42. These variations found be widely distributed throughout particularly accumulated non-structural proteins, might associated potential revert its original low pathogenic form subsequent horizontal transmission herds. data improve our knowledge regarding safety inherent risk reversion natural virulence host animals.