The impact of donor cytomegalovirus DNA on transfusion strategies for at‐risk patients

• DOI: 10.1111/trf.12199
• Publication Date: 2013-04-15T04:48:49Z
• Authors: Malte Ziemann; David Juhl; Siegfried Görg; Holger Hennig
• Keywords: Cytomegalovirus

Background C ytomegalovirus ( CMV ) DNA is frequently detected in plasma of newly seropositive donors. Selection leukoreduced blood products from donors with remote infection could avoid transfusion‐transmitted infections TT ‐ due to primarily infected However, there are no data about the prevalence reactivations long‐term compared incidence window period donations seronegative Therefore, optimal transfusion strategy for at‐risk patients unclear. Study Design and Methods Whole samples 22,904 were tested , –positive categorized as 1) donors, 2) 3) Results Twenty‐one reproducibly (0.09%). Frequency detection concentration whole comparable Nonreproducibly positive results more frequent (0.16% vs. 0.01%, p < 0.01). Only low concentrations detectable two one donor. Highest both plasma, however, found Conclusion Prevalences among well these comparable. groups be used at risk while those seem bear an increased risk.