The value of transfusion of phenotyped blood units for thalassemia and sickle cell anemia patients at an academic center

• DOI: 10.1111/trf.15682
• Publication Date: 2020-03-05T11:06:36Z
• Authors: Salwa Hindawi; Maha Badawi; Refaat Elfayoumi; Tarek Elgemmezi; Abrar Al Hassani; Mohamed Raml; Seraj Alamoudi; Kholoud Gholam
• Keywords: Single Center; Transfusion medicine

BACKGROUND Blood transfusion is the first‐line treatment for patients with thalassemia and many sickle cell patients. However, cases of unregulated blood are shown to carry a high risk alloimmunization red cells (RBCs), which can lead hemolytic reaction be fatal Screening identification alloantibodies are, therefore, essential practice in services. Transfusion phenotyped minimize these risks STUDY DESIGN AND METHODS A prospective study was carried out on 1015 donors, retrospective 208 multiple transfused β‐thalassemia anemia. Donor patient samples were subjected Rh & K typing, also screening RBC antibodies. We aimed determine prevalence antigens patients, as well at King Abdulaziz University Hospital frequency selected RESULTS The most commonly detected Rh‐phenotype donors R1r (32.02%), followed by R1R1 (23.25%). Only 9.16% positive antigen. group reported: highest (40.86%) R1R2 (24.04%) only (6.25%) rate among anemia 39.42% 35.57%, respectively. specificity rates recorded anti‐E anti‐K both groups. CONCLUSION particularly observed against antigens. This emphasizes clinical need typing RBCs prior so provide matched units associated morbidities alloimmunization. Keeping database clinically effective safe management