Phenibut toxicosis in a dog

• DOI: 10.1111/vec.13313
• Publication Date: 2023-07-12T16:29:23Z
• Authors: Michael Sahagian; Alicia Mastrocco; Jennifer Prittie
• Keywords: Hypertonia

Abstract Objective To describe the successful treatment of severe neurological and cardiovascular abnormalities in a dog following ingestion neuropsychotropic drug, phenibut. Case Summary A 2‐year‐old neutered male Weimaraner was found unresponsive laterally recumbent his urine after ingesting approximately 1600 mg/kg On presentation to an emergency clinic, neurologically inappropriate, tachycardic, hypertensive, exhibiting profoundly decreased respiratory rate. Because progressive clinical signs, electrolyte abnormalities, increased hepatic enzyme activity bilirubin concentrations, development pigmenturia, referral specialist care sought. presentation, intermittently somnolent then maniacal. Sinus tachycardia persisted, hyperthermia documented. Hospitalization for supportive undertaken, administered IV fluids, flumazenil, antiepileptics, lipid emulsion therapy. The developed hypoglycemia treated with dextrose supplementation. Progressive increases liver activities as well pronounced increase creatine kinase activity, consistent rhabdomyolysis, were noted. Over course 48 hours, resolved, signs significantly improved. Ultimately, discharged improved owner reporting that 1 week discharge, full recovery had been made, no residual persisted. New Information Provided authors’ knowledge, there are previous reports phenibut intoxication small animals. growing availability use this drug by people past several years highlight need greater understanding its effects companion