Protective effect of dimethyl fumarate for the development of pressure ulcers after cutaneous ischemia‐reperfusion injury

• DOI: 10.1111/wrr.12824
• Publication Date: 2020-05-01T04:10:52Z
• Authors: Yuta Inoue; Akihiko Uchiyama; Akiko Sekiguchi; Sahori Yamazaki; Chisako Fujiwara; Yoko Yokoyama; Sachiko Ogino; Ryoko Torii; Mari Hosoi; Ryoko Akai; Takao Iwawaki; Osamu Ishikawa; Sei‐ichiro Motegi
• Keywords: Proinflammatory cytokine; Dimethyl fumarate; Infiltration (HVAC)

Ischemia-reperfusion (I/R) is associated with various pathogenic conditions, and there has been increasing evidence that cutaneous I/R injury the pathogenesis of pressure ulcers (PUs), especially at early stage presenting as non-blanchable erythema. Several studies demonstrated oxidative stress a key player in injury, inhibition may be capable protecting tissue damage after organs including skin. Dimethyl fumarate (DMF) approved by Food Drug Administration Nrf2 activator, recent revealed antioxidative anti-inflammatory effects DMF on animal models. Our objective was to assess oral administration development PUs mice. We found significantly decreased size I/R. Cutaneous I/R-induced also inhibited OKD48 mice, which can visually assessed. In addition, treatment hypoxic area, numbers apoptotic cells, vascular loss area. suppressed infiltration MPO+ neutrophils production proinflammatory cytokines site injury. vitro experiments, reactive oxygen species pericyte-like cells. These results suggest might prevent formation induced via suppressing subsequent inflammation. during phase decubitus protect against further progression.