Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL‐1 atrial myocytes

• DOI: 10.1113/jp284474
• Publication Date: 2023-12-15T07:10:59Z
• Authors: Yang Guo; Delfine Cheng; Ze‐Yan Yu; Teresa Schiatti; Andrea Y. Chan; Adam P. Hill; Rémi Peyronnet; Michael P. Feneley; Charles D. Cox; Boris Martinac
• Keywords: Piezo1

The transient receptor potential melastatin 4 (TRPM4) channel contributes extensively to cardiac electrical activity, especially cardiomyocyte action formation. Mechanical stretch can induce changes in heart rate and rhythm, the mechanosensitive Piezo1 is expressed many cell types within myocardium. Our previous study showed that TRPM4 are closely co-localized t-tubules of ventricular cardiomyocytes contribute Ca