Glucose Ingestion Attenuates Interleukin‐6 Release from Contracting Skeletal Muscle in Humans

• DOI: 10.1113/jphysiol.2003.042374
• Publication Date: 2003-04-22T00:14:24Z
• Authors: Mark A. Febbraio; Adam Steensberg; Charlotte Keller; Rebecca L. Starkie; Henning B. Nielsen; Peter Krustrup; Peter Ott; Niels H. Secher; Bente K. Pedersen
• Keywords: Oral; Adult; Male; Messenger; Administration, Oral; Fatty Acids, Nonesterified; Research Support; Placebos; 03 medical and health sciences; 0302 clinical medicine; Journal Article; Humans; RNA, Messenger; Non-U.S. Gov't; Muscle, Skeletal; Leg; Interleukin-6; Research Support, Non-U.S. Gov't; Fatty Acids; Skeletal; Femoral Vein; Clinical Trial; Bicycling; Glucose; Regional Blood Flow; Administration; Randomized Controlled Trial; Nonesterified; Muscle; RNA; Muscle Contraction

To examine whether glucose ingestion during exercise affects the release of interleukin-6 (IL-6) from contracting limb, seven men performed 120 min semi-recumbent cycling on two occasions while ingesting either 250 ml a 6.4 % carbohydrate (GLU trial) or sweet placebo (CON beverage at onset of, and 15 intervals throughout, exercise. Muscle biopsies obtained before immediately after were analysed for glycogen IL-6 mRNA expression. Blood samples simultaneously brachial artery femoral vein prior to leg blood flow was measured by thermodilution in vein. Net release, net free fatty acid (FFA) uptake, calculated these measurements. The arterial concentration lower (P < 0.05) GLU, but neither intramuscular nor different when comparing GLU with CON. However, attenuated compared This corresponded an enhanced uptake reduced FFA GLU. These results demonstrate that attenuates does not decrease expression mRNA.