Passive acoustic mapping within the cranial vault during microbubble-mediated ultrasound brain therapy

• DOI: 10.1121/10.0018976
• Publication Date: 2023-04-26T18:08:28Z
• Authors: Ryan M. Jones; Dallan McMahon; Lulu Deng; Meaghan O'Reilly; Kullervo Hynynen
• Keywords: Cranial vault; Transcranial Doppler

Over the past 15 years, use of passive sensor arrays combined with established beamforming algorithms to image acoustic activity during ultrasound therapies, so-called mapping (PAM), has been increasingly investigated for cavitation-based treatment monitoring and control purposes. Our group is interested in applications microbubble-mediated therapy brain, which skull bone presents unique challenges both delivery emissions monitoring. We have demonstrated that skull-specific transcranial aberration correction methods can be applied receive augment PAM quality through bone, borrowing techniques developed originally transmit beam focusing. Using custom clinical-prototype transmit/receive phased arrays, we performed 3D microbubble imaging vivo ex human skullcaps, exploited resulting spatiotemporal cavitation information real-time exposure level calibration offline bioeffect distribution prediction. Ultrafast processing data uncover dynamics hidden by conventional whole-burst temporal averaging, as well inform under-sampling strategies when millisecond-long tone bursts are applied. This talk will provide a historical overview throughout body, followed summary recent progress made within cranial vault brain applications.