Blockade of AT1 Receptor Reduces Apoptosis, Inflammation, and Oxidative Stress in Normotensive Rats with Intracerebral Hemorrhage

• DOI: 10.1124/jpet.107.120097
• Publication Date: 2007-05-31T01:05:11Z
• Authors: Keun-Hwa Jung; Kon Chu; Soon-Tae Lee; Se-Jeong Kim; Eun-Cheol Song; Eun-Hee Kim; Dong-Kyu Park; Dong-In Sinn; Jeong-Min Kim; Manho Kim; Jae-Kyu Roh
• Keywords: Telmisartan; Terminal deoxynucleotidyl transferase

Angiotensin II exerts its central nervous system effects primarily via receptors AT1 and AT2, it participates in the pathogenesis of ischemia AT1. The selective receptor blocker (ARB) is used hypertension treatment, a variety pleiotropic effects, including antioxidative, antiapoptotic, anti-inflammatory effects. In this study, we investigated therapeutic effect ARB telmisartan experimental intracerebral hemorrhage (ICH) normotensive rats. ICH was induced collagenase infusion or autologous blood injection. Either at 30 mg/kg/dose phosphate-buffered saline orally administered 2 h after induction. We evaluated volume, brain water content, functional recovery, performed histological analysis for terminal deoxynucleotidyl transferase dUTP nick-end labeling, leukocyte infiltration, microglia activation. A intracellular signals, terms oxidative stress, apoptotic molecules, inflammatory mediators, were also measured. Telmisartan reduced edema, cells perihematomal area. noted to induce expression endothelial nitric-oxide synthase peroxisome proliferator-activated γ decrease signal, tumor necrosis factor-α, cyclooxygenase-2 expression. telmisartan-treated rats exhibited less pronounced neurological deficits recovered better. Thus, seems offer neural protection, antiapoptosis, anti-inflammatory, antioxidant benefits rat model.