Reorganization of chromosome architecture in replicative cellular senescence

• DOI: 10.1126/sciadv.1500882
• Publication Date: 2017-08-10T23:24:10Z
• Authors: Steven W. Criscione; Marco De Cecco; Benjamin Siranosian; Yue Zhang; Jill A. Kreiling; John M. Sedivy; Nicola Neretti
• Keywords: Cellular senescence; Senescence; Cellular Aging; Cellular architecture

Senescent cells acquire a unique chromosome architecture characterized by genome-wide shrinkage of arms.