Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs

• DOI: 10.1126/sciadv.1700398
• Publication Date: 2017-07-20T01:00:23Z
• Authors: Bridgett M. vonHoldt; Emily Shuldiner; Ilana Janowitz Koch; Rebecca Y. Kartzinel; Andrew Hogan; Lauren Brubaker; Shelby Wanser; Daniel Stahler; Clive D. L. Wynne; Elaine A. Ostrander; Janet S. Sinsheimer; Monique A. R. Udell
• Keywords: Williams Syndrome; 0301 basic medicine; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; 03 medical and health sciences; Dogs; Genetics; 2.1 Biological and endogenous factors; Animals; Humans; Genetic Predisposition to Disease; Dog Diseases; Aetiology; Polymorphism; Social Behavior; Research Articles; Genetic Association Studies; Behavior; Behavior, Animal; Animal; Computational Biology; Genetic Variation; Reproducibility of Results; Molecular Sequence Annotation; Single Nucleotide; Biological Sciences; Stereotyped Behavior; Biotechnology

We hypothesize that selection during dog domestication targeted CNVs associated with hypersociability.