Hierarchical assembly governs TRIM5α recognition of HIV-1 and retroviral capsids

• DOI: 10.1126/sciadv.aaw3631
• Publication Date: 2019-11-28T00:16:01Z
• Authors: Katarzyna A. Skor...; Marcin D. Roganowicz; Devin E. Christensen; Yueping Wan; Owen Pornillos; Barbie K. Ganser-...
• Keywords: Antiviral Restriction Factors; Tripartite Motif Proteins; 0301 basic medicine; 03 medical and health sciences; Capsid; Ubiquitin-Protein Ligases; Virus Assembly; Cryoelectron Microscopy; HIV-1; Humans; Research Articles; 3. Good health

TRIM5α combines distinct modes of binding into successively higher-order structures to recognize HIV-1 and retroviral capsids.