Two-dimensional nuclear magnetic resonance spectroscopy with a microfluidic diamond quantum sensor

• DOI: 10.1126/sciadv.aaw7895
• Publication Date: 2019-07-26T23:15:19Z
• Authors: Janis Smits; Joshua T. Damron; Pauli Kehayias; Andrew F. McDowell; Nazanin Mosavian; Ilja Fescenko; Nathaniel Ristoff; Abdelghani Laraoui; Andrey Jarmola; Victor M. Acosta
• Keywords: Quantum sensor; Spectral resolution

Quantum sensors based on nitrogen-vacancy centers in diamond have emerged as a promising detection modality for nuclear magnetic resonance (NMR) spectroscopy owing to their micrometer-scale volume and noninductive-based detection. A remaining challenge is realize sufficiently high spectral resolution concentration sensitivity multidimensional NMR analysis of picoliter sample volumes. Here, we address this by spatially separating the polarization phases experiment microfluidic platform. We 0.65 ± 0.05 Hz, an order-of-magnitude improvement over previous studies. use platform perform two-dimensional correlation liquid analytes within effective ∼40-picoliter volume. The quantum in-line detectors major step toward applications mass-limited chemical single-cell biology.