A prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells

• DOI: 10.1126/sciadv.aax0064
• Publication Date: 2019-08-21T23:41:39Z
• Authors: Jingen Zhu; Pan Tao; Marthandan Mahali...; Jian Sha; Paul Kilgore; Ashok K. Chopra; Venigalla Rao
• Keywords: 0301 basic medicine; Genetic Vectors; Gene Transfer Techniques; Eukaryota; Endosomes; Dependovirus; Cell Line; 3. Good health; Mice; 03 medical and health sciences; Eukaryotic Cells; Transduction, Genetic; Viruses; Vaccines, DNA; Animals; Bacteriophage T4; Humans; Nanoparticles; Transgenes; Antigens; Genetic Engineering; Research Articles

An engineered viral vector of bacteriophage T4 linked to AAV delivers large payloads genes and proteins into human cells.