Targeting CCR5 trafficking to inhibit HIV-1 infection

• DOI: 10.1126/sciadv.aax0821
• Publication Date: 2019-10-16T23:25:22Z
• Authors: Gaelle Boncompain; Floriane Herit; Sarah Tessier; Aurianne Lescure; Elaine Del Nery; Pierre Gestraud; Isabelle Staropoli; Yuko Fukata; Masaki Fukata; Anne Brelot; Florence Niedergang; Franck Perez
• Keywords: 0301 basic medicine; Receptors, CXCR4; Secretory Pathway; Receptors, CCR5; Macrophages; Receptors, CCR1; HIV Infections; Cell Line; 3. Good health; Protein Transport; 03 medical and health sciences; HEK293 Cells; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases; Cell Line, Tumor; 616; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology; HIV-1; Humans; Amino Acid Sequence; Research Articles; HeLa Cells

The diversity of secretory routes enabled the identification of specific inhibitors of CCR5 transport and HIV-1 infection.