Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death

• DOI: 10.1126/sciadv.aax7945
• Publication Date: 2020-03-20T23:10:33Z
• Authors: S. Busker; W. Qian; M. Haraldsson; B. Espinosa; L. Johansson; S. Attarha; I. Kolosenko; J. Liu; M. Dagnell; D. Grandér; E. S. J. Arnér; K. Pokrovskaja Tamm; B. D. G. Page
• Keywords: STAT3 Transcription Factor; Transcriptional Activation; 0301 basic medicine; Thioredoxin Reductase 1; Cell Death; Dose-Response Relationship, Drug; NF-E2-Related Factor 2; Cell- och molekylärbiologi; Antineoplastic Agents; 3. Good health; Gene Expression Regulation, Neoplastic; Oxidative Stress; 03 medical and health sciences; Genes, Reporter; Cell Line, Tumor; Humans; Enzyme Inhibitors; Oxidation-Reduction; Cell and Molecular Biology; Research Articles

Redox regulation of STAT3 is targeted by direct inhibition of TrxR1, illuminating a promising link for therapeutic development.