Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity

• DOI: 10.1126/sciadv.aax8286
• Publication Date: 2020-01-30T00:14:42Z
• Authors: Tao Ni; Fang Jiao; Xiulian Yu; Saša Aden; Lucy Ginger; Sophie I. Williams; Fangfang Bai; Vojtěch Pražák; Dimple Karia; Phillip Stansfeld; Peijun Zhang; George Munson; Gregor Anderluh; Simon Scheuring; Robert J. C. Gilbert
• Keywords: Mammals; Phagocytes; 0303 health sciences; Bacteria; Protein Conformation; Macrophages; Immunity, Innate; Evolution, Molecular; Mice; Profilins; 03 medical and health sciences; Animals; Humans; Research Articles

Bactericidal perforin-2 assembles an inactivated pre-pore complex and undergoes a 180° reconfiguration for membrane attack.