High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease

• DOI: 10.1126/sciadv.aax9484
• Publication Date: 2019-12-12T00:19:34Z
• Authors: Kristian Parey; Outi Haapanen; Vivek Sharma; Harald Köfeler; Thomas Züllig; Simone Prinz; Karin Siegmund; Ilka Wittig; Deryck J. Mills; Janet Vonck; Werner Kühlbrandt; Volker Zickermann
• Keywords: NADH-UBIQUINONE OXIDOREDUCTASE; 0301 basic medicine; Protein Conformation; ACTIVE/DE-ACTIVE TRANSITION; NDUFS4; 610; Yarrowia; MITOCHONDRIAL; 03 medical and health sciences; Adenosine Triphosphate; Humans; CRYSTAL-STRUCTURE; ddc:610; Research Articles; ddc:610; Electron Transport Complex I; IDENTIFICATION; Cryoelectron Microscopy; Mitochondria; Physical sciences; MOLECULAR-DYNAMICS; SUBUNIT; Mitochondrial Membranes; FORCE-FIELD; ORIENTATION

Cryo-EM, yeast genetics, and simulations offer an integrated approach to assess structure, function, and assembly of complex I.