Avalanches and power law behavior in aortic dissection propagation

• DOI: 10.1126/sciadv.aaz1173
• Publication Date: 2020-05-22T23:06:02Z
• Authors: Xunjie Yu; Béla Suki; Yanhang Zhang
• Keywords: 0301 basic medicine; 03 medical and health sciences; 610; Research Articles; 3. Good health

Aortic dissection is a devastating cardiovascular disease known for its rapid propagation and high morbidity mortality. The mechanisms underlying the of aortic are not well understood. Our study reports discovery avalanche-like failure aorta during that results from local buildup strain energy followed by cascade inhomogeneously distributed interlamellar collagen fibers. An innovative computational model was developed successfully describes mechanics propagation. provides first quantitative agreement between experiment prediction within complex extracellular matrix (ECM). may lead to possibility predicting such catastrophic events based on microscopic features ECM.