Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage

• DOI: 10.1126/sciadv.aaz9115
• Publication Date: 2020-03-20T23:15:43Z
• Authors: Rajini Srinivasan; Nataliya Nady; Neha Arora; Laura J. Hsieh; Tomek Swigut; Geeta J. Narlikar; Mark Wossidlo; Joanna Wysocka
• Keywords: 0303 health sciences; Binding Sites; Gene Expression Regulation, Developmental; Zinc Fingers; Models, Biological; Nucleosomes; Mice; 03 medical and health sciences; Genes, Reporter; Animals; Nucleotide Motifs; Research Articles; Embryonic Stem Cells; DNA Damage; Microsatellite Repeats; Protein Binding; Repetitive Sequences, Nucleic Acid; Transcription Factors

A developmentally regulated mechanism, mediated by a zinc finger protein Zscan4, protects genome integrity in early embryos.