Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model

• DOI: 10.1126/sciadv.aba0466
• Publication Date: 2020-07-29T23:14:45Z
• Authors: Chun Chen; Eun Hee Ahn; Seong Su Kang; Xia Liu; Ashfaqul Alam; Keqiang Ye
• Keywords: Dysbiosis; Gut–brain axis; Amyloid (mycology)

The gut-brain axis is bidirectional, and gut microbiota influence brain disorders including Alzheimer's disease (AD). CCAAT/enhancer binding protein β/asparagine endopeptidase (C/EBPβ/AEP) signaling spatiotemporally mediates AD pathologies in the via cleaving both β-amyloid precursor Tau. We show that dysbiosis occurs 5xFAD mice, associated with escalation of C/EBPβ/AEP pathway age. Unlike aged wild-type 3xTg mice accelerate pathology young accompanied by active brain. Antibiotic treatment diminishes this attenuates amyloidogenic processes 5xFAD, improving cognitive functions. prebiotic R13 inhibits suppresses amyloid aggregates gut. R13-induced