Diversification of reprogramming trajectories revealed by parallel single-cell transcriptome and chromatin accessibility sequencing

• DOI: 10.1126/sciadv.aba1190
• Publication Date: 2020-09-11T23:18:25Z
• Authors: Q. R. Xing; C. A. El Farran; P. Gautam; Y. S. Chuah; T. Warrier; C. X. D. Toh; N. Y. Kang; S. Sugii; Y. T. Chang; J. Xu; J. J. Collins; G. Q. Daley; H. Li; L. F. Zhang; Y. H. Loh
• Keywords: DYNAMICS; 570; FATE; Molecular Plant Physiology; Muscle Proteins; Chromosomes; 03 medical and health sciences; Machinery; HUMAN FIBROBLASTS; BINDING; Humans; INDUCED PLURIPOTENCY; Research Articles; REGULATORS; 0303 health sciences; INDUCTION; SYSTEMATIC IDENTIFICATION; :Biological sciences [Science]; TEA Domain Transcription Factors; 540; Cellular Reprogramming; Chromatin; DNA-Binding Proteins; Single-Cell Analysis; Transcriptome; STEM-CELLS; Transcription Factors

Integrative single-cell analysis de-constructs the heterogeneity of human reprogramming and uncovers its stage-specific GRNs.