Human interleukin-4–treated regulatory macrophages promote epithelial wound healing and reduce colitis in a mouse model

• DOI: 10.1126/sciadv.aba4376
• Publication Date: 2020-06-05T23:17:28Z
• Authors: Timothy S. Jayme; Gabriella Leung; Arthur Wang; Matthew L. Worken...; Sruthi Rajeev; Adam Shute; Blanca E. Callejas; Nicole Mancini; Paul L. Beck; Remo Panaccione; Derek M. McKay
• Keywords: Wound Healing; 0303 health sciences; Macrophages; Colitis; Inflammatory Bowel Diseases; 3. Good health; Disease Models, Animal; Mice; 03 medical and health sciences; Animals; Humans; Interleukin-4; Research Articles

Human IL-4 macrophages promote epithelial wound recovery and suppress colitis, supporting their use as a cell therapy for IBD.