Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets

• DOI: 10.1126/sciadv.abb5398
• Publication Date: 2021-01-06T20:55:35Z
• Authors: Ryan A. Neff; Minghui Wang; Sezen Vatansever; Lei Guo; Chen Ming; Qian Wang; Erming Wang; Emrin Horgusluogl...; Won-min Song; Aiqun Li; Emilie L. Castranio; Julia TCW; Lap Ho; Alison Goate; Valentina Fossati; Scott Noggle; Sam Gandy; Michelle E. Ehrlich; Pavel Katsel; Eric Schadt; Dongming Cai; Kristen J. Brennand; Vahram Haroutunian; Bin Zhang
• Keywords: Subtyping

Three major molecular subtypes of Alzheimer’s disease are identified, cross-validated, and characterized across 1543 individuals.