Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response

• DOI: 10.1126/sciadv.abc1834
• Publication Date: 2021-03-24T19:15:55Z
• Authors: Dapeng Ma; Min Yang; Qiushi Wang; Caiyu Sun; Hongbiao Shi; Weiqiang Jing; Yuxuan Bi; Xuecheng Shen; Xiaomin Ma; Zhenzhi Qin; Yueke Lin; Lihui Zhu; Yunxue Zhao; Yeping Cheng; Lihui Han
• Keywords: 0301 basic medicine; Protein-Arginine N-Methyltransferases; Immunity; Intracellular Signaling Peptides and Proteins; Herpes Simplex; Arginine; Antiviral Agents; Nucleotidyltransferases; 3. Good health; Mice; 03 medical and health sciences; Animals; Research Articles

PRMT5 directly induces methylation of cGAS and inhibits cGAS-mediated antiviral immunity.