The structure-function relationship of oncogenic LMTK3

• DOI: 10.1126/sciadv.abc3099
• Publication Date: 2020-11-14T00:21:23Z
• Authors: Angeliki Ditsiou; Chiara Cilibrasi; Nikiana Simigdala; Athanasios Papaky...; Leanne Milton-Harris; Viviana Vella; Joanne E. Nettleship; Jae Ho Lo; Shivani Soni; Goar Smbatyan; Panagiota Ntavelou; Teresa Gagliano; Maria Chiara Iachini; Sahir Khurshid; Thomas Simon; Lihong Zhou; Storm Hassell-Hart; Philip Carter; Laurence H. Pearl; Robin L. Owen; Raymond J. Owens; S. Mark Roe; Naomi E. Chayen; Heinz-Josef Lenz; John Spencer; Chrisostomos Prod...; Apostolos Klinakis; Justin Stebbing; Georgios Giamas
• Keywords: Structure function; Structure–activity relationship

The structure of oncogenic LMTK3 determines its role and functions allowing drug inhibition as a new therapeutic strategy.