Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm

• DOI: 10.1126/sciadv.abe3024
• Publication Date: 2020-12-09T21:18:55Z
• Authors: Philip A. Mudd; Jeremy Chase Craw...; Jackson S. Turner; Aisha Souquette; Daniel Reynolds; Diane Bender; James P. Bosanquet; Nitin J. Anand; David A. Striker; R. Scott Martin; Adrianus C. M. Boon; Stacey L. House; Kenneth E. Remy; Richard S. Hotchkiss; Rachel M. Presti; Jane A. O’Halloran; William G. Powderly; Paul G. Thomas; Ali H. Ellebedy
• Keywords: Cytokine Storm; 2019-20 coronavirus outbreak; Pandemic; Betacoronavirus

We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and influenza patients. Compared to patients with influenza, COVID-19 exhibited largely equivalent lymphocyte counts, fewer monocytes, lower surface human leukocyte antigen (HLA)-class II expression on selected monocyte populations. Furthermore, decreased HLA-DR intermediate monocytes predicted severe disease. In contrast prevailing assumptions, very few (7 168) cytokine profiles indicative storm syndrome. After controlling for multiple factors including age sample time point, levels than influenza. Up-regulation IL-6, G-CSF, IL-1RA, MCP1 death but were not statistically higher Single-cell transcriptional profiling revealed profound suppression interferon signaling among COVID-19. When considered across the spectrum peripheral profiles, are less inflamed