The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters

• DOI: 10.1126/sciadv.abf0717
• Publication Date: 2021-02-19T20:54:55Z
• Authors: Florian A. Rosenb...; David Moore; Ilian Atanassov; Marco F. Moedas; Paula Clemente; Ákos Végvári; Najla El Fissi; Roberta Filograna; Anna-Lena Bucher; Yvonne Hinze; Matthew The; Erik Hedman; Ekaterina Chernog...; Arjana Begzati; Rolf Wibom; Mohit Jain; Roland Nilsson; Lukas Käll; Anna Wedell; Christoph Freyer; Anna Wredenberg
• Keywords: Sulfur Metabolism; Carbon fibers

Induction of the one-carbon cycle is an early hallmark mitochondrial dysfunction and cancer metabolism. Vital intermediary steps are localized to mitochondria, but it remains unclear how availability connects function. Here, we show that metabolite methyl group donor