Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR

• DOI: 10.1126/sciadv.abf0971
• Publication Date: 2021-05-26T19:17:54Z
• Authors: Sophie Kaspar; Christian Oertlin; Karolina Szczepan...; Alexandra Kukat; Katharina Senft; Christina Lucas; Susanne Brodesser; Maria Hatzoglou; Ola Larsson; Ivan Topisirovic; Aleksandra Trifun...
• Keywords: 0301 basic medicine; 03 medical and health sciences; Research Articles; 3. Good health

Upon mitochondrial dysfunction, CHOP acts as a rheostat that attenuates prolonged stress and delays the onset of cardiomyopathy.