In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease

• DOI: 10.1126/sciadv.abh1448
• Publication Date: 2021-10-29T18:00:48Z
• Authors: Georg Meisl; Eric Hidari; Kieren Allinson; Timothy Rittman; Sarah L. DeVos; Justin S. Sanchez; Catherine K. Xu; Karen E. Duff; Keith A. Johnson; James B. Rowe; Bradley T. Hyman; Tuomas P. J. Knowles; David Klenerman
• Keywords: 0301 basic medicine; Aging; FOS: Clinical medicine; Neurosciences; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Neurodegenerative; 3101 Biochemistry and Cell Biology; Alzheimer's Disease; Brain Disorders; 3. Good health; 03 medical and health sciences; Neurological; Acquired Cognitive Impairment; Dementia; Neuroscience; 31 Biological Sciences

Local replication doubles the number of tau aggregate in Alzheimer’s disease only once every 5 years, limiting the overall rate.