Lactate supports a metabolic-epigenetic link in macrophage polarization

• DOI: 10.1126/sciadv.abi8602
• Publication Date: 2021-11-12T18:56:46Z
• Authors: Jordan T. Noe; Beatriz E. Rendon; Anne E. Geller; Lindsey R. Conroy; Samantha M. Morri...; Lyndsay E.A. Young; Ronald C. Bruntz; Eun J. Kim; Ashley Wise-Mitchell; Mariana Barbosa d...; Eric R. Relich; Becca V. Baby; Lance A. Johnson; Hayley C. Affronti; Kelly M. McMasters; Brian F. Clem; Matthew S. Gentry; Jun Yan; Kathryn E. Wellen; Ramon C. Sun; Robert A. Mitchell
• Keywords: 0303 health sciences; 03 medical and health sciences; Biomedicine and Life Sciences

Macrophages use mitochondrial lactate metabolism for ACLY-dependent histone acetylation, immune suppression, and tumor progression.