KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer

• DOI: 10.1126/sciadv.abl4618
• Publication Date: 2022-02-16T18:51:30Z
• Authors: Kee-Beom Kim; Ashish Kabra; Dong-Wook Kim; Yongming Xue; Yuanjian Huang; Pei-Chi Hou; Yunpeng Zhou; Leilani J. Miranda; Jae-Il Park; Xiaobing Shi; Timothy P. Bender; John H. Bushweller; Kwon-Sik Park
• Keywords: CREB-binding protein

EP300, a transcription coactivator important in proliferation and differentiation, is frequently mutated diverse cancer types, including small cell lung (SCLC). While these mutations are thought to result loss of EP300 function, the impact on tumorigenesis remains largely unknown. Here, we demonstrate that mutants lacking acetyltransferase domain accelerate tumor development mouse models SCLC. However, unexpectedly, complete