Ultrasound-responsive catalytic microbubbles enhance biofilm elimination and immune activation to treat chronic lung infections

• DOI: 10.1126/sciadv.ade5446
• Publication Date: 2023-01-25T18:58:27Z
• Authors: Weijun Xiu; Lili Ren; Huayu Xiao; Yue Zhang; Dou Wang; Kaili Yang; Siyu Wang; Lihui Yuwen; Xiao Li; Heng Dong; Qiang Li; Yongbin Mou; Yuqian Zhang; Zhaowei Yin; Bin Liang; Yu Gao; Lianhui Wang
• Keywords: Piperacillin; 0301 basic medicine; Mice; 03 medical and health sciences; Microbubbles; Biofilms; Pseudomonas aeruginosa; Animals; Bacterial Infections; Lung; 3. Good health; Anti-Bacterial Agents

Efficient treatment of chronic lung infections caused by Pseudomonas aeruginosa biofilms is a great challenge because drug tolerance and immune evasion issues. Here, we develop ultrasound-responsive catalytic microbubbles with biofilm elimination activation properties to combat infection induced P. biofilms. In these microbubbles, piperacillin Fe3O4 nanoparticles form drug-loaded shell surrounding the air core. Under ultrasound stimulation, can physically disrupt structure enhance penetration both into biofilm. Then, chemically degrade matrix kill bacteria assistance piperacillin. activate response for polarizing macrophages pro-inflammatory phenotype. These efficiently treat in mouse model combining physical/chemical/antibiotic activation, thus providing promising strategy combating bacterial infections.