Endothelial RIPK1 protects artery bypass graft against arteriosclerosis by regulating SMC growth

• DOI: 10.1126/sciadv.adh8939
• Publication Date: 2023-08-30T17:58:56Z
• Authors: Yao Lu; Yiming Leng; Yalan Li; Jie Wang; Wei Wang; Ruilin Wang; Yuanyuan Liu; Qian Tan; Wenjing Yang; Youxiang Jiang; Jingjing Cai; Hong Yuan; Liang Weng; Qingbo Xu
• Keywords: Neointima; Endothelial Dysfunction; Knockout mouse

RIPK1 is crucial in the inflammatory response. The process of vascular graft remodeling also involved endothelial inflammation, which can influence behavior smooth muscle cells. However, role arterial bypass grafts remains unknown. Here, we established an isograft mouse model wild-type and conditional knockout mice. Progressive neointima formation occurred artery, showing SMC accumulation together with adhesion molecule cytokine expression. Endothelial exacerbated stenosis by increasing secretion N-Shh. Mechanistically, directly phosphorylated EEF1AKMT3 at Ser