A 10-micrometer-thick nanomesh-reinforced gas-permeable hydrogel skin sensor for long-term electrophysiological monitoring

• DOI: 10.1126/sciadv.adj5389
• Publication Date: 2024-01-10T18:59:55Z
• Authors: Zongman Zhang; Jiawei Yang; Haoyang Wang; Chunya Wang; Yuheng Gu; Yumiao Xu; Sunghoon Lee; Tomoyuki Yokota; Hossam Haick; Takao Someya; Yan Wang
• Keywords: Nanomesh; Bioelectronics

Hydrogel-enabled skin bioelectronics that can continuously monitor health for extended periods is crucial early disease detection and treatment. However, it challenging to engineer ultrathin gas-permeable hydrogel sensors self-adhere the human long-term daily use (>1 week). Here, we present a ~10-micrometer-thick polyurethane nanomesh-reinforced sensor continuous high-quality electrophysiological monitoring 8 days under life conditions. This research involves two key steps: (i) material design by gelatin-based thermal-dependent phase change hydrogels (ii) robust thinness geometry achieved through nanomesh reinforcement. The resulting exhibit thickness of ~10 micrometers with superior mechanical robustness, high adhesion, gas permeability, anti-drying performance. To highlight potential applications in treatment leverage collective features, demonstrate long-term, high-precision conditions up days.