Role of the ABC Transporter Mdl1 in Peptide Export from Mitochondria

• DOI: 10.1126/science.1056957
• Publication Date: 2002-07-27T09:47:44Z
• Authors: Lesley Young; Klaus Leonhard; Takashi Tatsuta; John Trowsdale; Thomas Langer
• Keywords: Intermembrane space; Proteolysis; Inner membrane; Mitochondrial intermembrane space

ATP-binding cassette (ABC) adenosine triphosphatases actively transport a wide variety of compounds across biological membranes. Here, the ABC protein Mdl1 was identified as an intracellular peptide transporter localized in inner membrane yeast mitochondria. required for mitochondrial export peptides with molecular masses ∼2100 to 600 daltons generated by proteolysis inner-membrane proteins m-AAA protease matrix. Proteolysis i-AAA intermembrane space led release similar-sized independent Mdl1. Thus, two pathways efflux from mitochondria exist that may allow communication between and their cellular environment.