BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF

• DOI: 10.1126/science.1061965
• Publication Date: 2002-07-27T09:52:08Z
• Authors: Jeffrey S. Thompson; Sarah A. Bixler; Fang Qian; Kalpit Vora; Martin L. Scott; Teresa G. Cachero; Catherine Hession; Pascal Schneider; Irene D. Sizing; Colleen Mullen; Kathy Strauch; Mohammad Zafari; Christopher D. Be...; Jurg Tschopp; Jeffrey L. Browning; Christine Ambrose
• Keywords: Male; B-Lymphocytes; Lymphoid Tissue; Mice, Inbred A; Chromosomes, Human, Pair 22; Molecular Sequence Data; Chromosome Mapping; Membrane Proteins; Ligands; Cell Line; Mice, Inbred C57BL; Mice; B-Cell Activating Factor; Animals; Homeostasis; Humans; Amino Acid Sequence; B-Cell Maturation Antigen; Cloning, Molecular; B-Cell Activation Factor Receptor

B cell homeostasis has been shown to critically depend on BAFF, the activation factor from tumor necrosis (TNF) family. Although BAFF is already known bind two receptors, BCMA and TACI, we have identified a third receptor for that termed BAFF-R. BAFF-R binding appears be highly specific suggesting unique role this ligand-receptor interaction. Consistent with this, locus disrupted in A/WySnJ mice, which display phenotype qualitatively similar of BAFF-deficient mice. Thus, principal BAFF-mediated mature survival.