Priming of Memory But Not Effector CD8 T Cells by a Killed Bacterial Vaccine

• DOI: 10.1126/science.1064571
• Publication Date: 2002-07-27T09:47:15Z
• Authors: Gregoire Lauvau; Sujata Vijh; Philip Kong; Tiffany Horng; Kristen Kerksiek; Natalya Serbina; Roman A. Tuma; Eric G. Pamer
• Keywords: Priming (agriculture); Cellular immunity

Killed or inactivated vaccines targeting intracellular bacterial and protozoal pathogens are notoriously ineffective at generating protective immunity. For example, vaccination with heat-killed Listeria monocytogenes (HKLM) is not protective, although infection live L. induces long-lived, CD8 T cell–mediated We demonstrate that HKLM immunization primes memory lymphocyte populations that, substantial in size, providing protection from subsequent infection. In contrast to infection, which elicits large numbers of effector cells, lymphocytes do acquire functions. Our studies show it possible dissociate cell–dependent immunity cell expansion, generation cells may be necessary for long-term