Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins

• DOI: 10.1126/science.1074683
• Publication Date: 2002-10-24T21:03:20Z
• Authors: Stephen J. Perry; George S. Baillie; Trudy A. Kohout; Ian McPhee; Maria M. Magiera; Kok Long Ang; William E. Miller; Alison J. McLean; Marco Conti; Miles D. Houslay; Robert J. Lefkowitz
• Keywords: Second messenger system; PDE10A; Arrestin

Catecholamines signal through the beta2-adrenergic receptor by promoting production of second messenger adenosine 3',5'-monophosphate (cAMP). The magnitude this is restricted desensitization receptors their binding to beta-arrestins and cAMP degradation phosphodiesterase (PDE) enzymes. We show that coordinate both processes recruiting PDEs activated in plasma membrane mammalian cells. In doing so, limit activation membrane-associated cAMP-activated protein kinase simultaneously slowing rate increasing its at membrane.