Two Dobzhansky-Muller Genes Interact to Cause Hybrid Lethality in Drosophila

• DOI: 10.1126/science.1133953
• Publication Date: 2006-11-23T19:42:43Z
• Authors: Nicholas J. Brideau; Heather A. Flores; Jun Wang; Shamoni Maheshwari; Xu Wang; Daniel A. Barbash
• Keywords: Melanogaster

The Dobzhansky-Muller model proposes that hybrid incompatibilities are caused by the interaction between genes have functionally diverged in respective hybridizing species. Here, we show Lethal rescue ( Lhr ) has Drosophila simulans and interacts with Hybrid male Hmr ), which D. melanogaster , to cause lethality F1 males. LHR localizes heterochromatic regions of genome extensively sequence these species a manner consistent positive selection. Rapidly evolving DNA sequences may be driving evolution this incompatibility gene.