Differential Antigen Processing by Dendritic Cell Subsets in Vivo

• DOI: 10.1126/science.1136080
• Publication Date: 2007-01-05T08:57:59Z
• Authors: Diana Dudziak; Alice O. Kamphorst; Gordon F. Heidkamp; Veit R. Buchholz; Christine Trumpfh...; Sayuri Yamazaki; Cheolho Cheong; Kang Liu; Han-Woong Lee; Chae Gyu Park; Ralph M. Steinman; Michel C. Nussenz...
• Keywords: Antigen processing; Cross-Presentation

Dendritic cells (DCs) process and present self foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation antigen, but little known about how DCs control antigen in vivo. To examine processing vivo, we specifically targeted two major subsets using chimeric monoclonal antibodies. Unlike CD8 + express cell surface protein CD205, – DCs, which are positive for 33D1 specialized on histocompatibility complex (MHC) class II. This difference intrinsic DC associated with increased expression proteins involved MHC processing.