Revisiting the Role of the Mother Centriole in Centriole Biogenesis

• DOI: 10.1126/science.1142950
• Publication Date: 2007-04-27T01:03:40Z
• Authors: A. Rodrigues-Martins; M. Riparbelli; G. Callaini; D. M. Glover; M. Bettencourt-Dias
• Keywords: Centriole; Basal body

Centrioles duplicate once in each cell division cycle through so-called templated or canonical duplication. SAK, also called PLK4 (SAK/PLK4), a kinase implicated tumor development, is an upstream regulator of biogenesis necessary for centriole formation. We found that overexpression SAK/PLK4 could induce amplification centrioles Drosophila embryos and their de novo formation unfertilized eggs. Both processes required the activity DSAS-6 DSAS-4, two molecules Thus, template-free self-assembly process triggered regulated by ordinarily associate with existing centriole. The mother not bona fide template but platform set regulatory catalyzes regulates daughter assembly.