The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation

• DOI: 10.1126/science.1195271
• Publication Date: 2010-11-05T02:34:02Z
• Keywords: Affect; Presentation (obstetrics)

Getting HIV Under Control Approximately 1 in 300 people infected with are “controllers” who able to maintain long-term control of the virus without medication and do not progress AIDS. Uncovering genetic basis for this ability is great interest. Pereyra et al. (p. 1551 , published online 4 November; see Perspective by McMichael Jones ) now present genome-wide association results from patients enrolled International Controllers Study. The analysis compared controllers European, African-American, Hispanic descent progressors found >300 variants that reached significance, all which were major histocompatibility class I (HLA) region on chromosome 6. Analysis effects individual amino acids within classical HLA proteins revealed six independently significant residues, five lined peptide-binding groove. Thus, differences binding viral peptide antigens may be factors underlying between progressors.